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Terbinafine, a Novel Therapeutic Drug in the Treatment of Liver Cancer
Inventors
Prof. YU Jun
Department
Department of Medicine and Therapeutics
Key Problem and Market Opportunity
- Non-alcoholic fatty liver disease (NAFLD) is a heterogeneous condition defined by ectopic fat deposition in the liver that is not caused by alcohol consumption, which currently the most common form of liver disease in the West and Asia
- However, owing to unknown mechanism, targeted therapy is currently unavailable
- To develop terbinafine as a novel therapeutic drug for NAFLD-associated liver cancer
Key Advantages of the Technology
- Terbinafine, a SQLE inhibitor, is an FDA-approved antifungal agent
- Terbinafine can be repurposed to target SQLE, an oncogenic factor, in NAFLD-associated liver cancer
- Animal studies showed that Terbinafine effective suppressed NAFLD-associated liver cancer and improved survival with no apparent side effects
Potential Applications
- Terbinafine demonstrated good safety on suppressing NAFLD-associated liver cancer preclinically
- Proof-of-concept evidences on the therapeutic use of terbinafine for preventing NAFLD-HCC
Photos
SQLE is an oncogene in NAFLD-associated liver cancer
Terbinafine inhibits NAFLD-associated liver cancer in multiple animal models.
Terbinafine, a Novel Therapeutic Drug in the Treatment of Liver Cancer
Inventors
Prof. YU Jun
Department
Department of Medicine and Therapeutics
Key Problem and Market Opportunity
- Non-alcoholic fatty liver disease (NAFLD) is a heterogeneous condition defined by ectopic fat deposition in the liver that is not caused by alcohol consumption, which currently the most common form of liver disease in the West and Asia
- However, owing to unknown mechanism, targeted therapy is currently unavailable
- To develop terbinafine as a novel therapeutic drug for NAFLD-associated liver cancer
Key Advantages of the Technology
- Terbinafine, a SQLE inhibitor, is an FDA-approved antifungal agent
- Terbinafine can be repurposed to target SQLE, an oncogenic factor, in NAFLD-associated liver cancer
- Animal studies showed that Terbinafine effective suppressed NAFLD-associated liver cancer and improved survival with no apparent side effects
Potential Applications
- Terbinafine demonstrated good safety on suppressing NAFLD-associated liver cancer preclinically
- Proof-of-concept evidences on the therapeutic use of terbinafine for preventing NAFLD-HCC
Photos
SQLE is an oncogene in NAFLD-associated liver cancer
Terbinafine inhibits NAFLD-associated liver cancer in multiple animal models.
Categories
Medical Imaging
CUHK Tech ID
P-2018-0807
Patents
US20190271698A1 CN110218788A
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