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Streptococcus thermophilus and its Secreted Molecules for the Prevention of Colorectal Cancer
Inventors
Prof. WU Ka Kei
Department
Department of Anaesthesia and Intensive Care
Key Problem and Market Opportunity
- Colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of cancer death globally
- Recently, a healthy microbiota of the gut have been associated with the prevention of CRC development
- To develop a probiotic for preventing colorectal cancer
Key Advantages of the Technology
- S thermophilus was found to be depleted in patients with colorectal cancer
- Replenishing S thermophilus inhibited tumor formation in two mouse models of colorectal cancer
- S thermophilus was found to secrete beta-galactosidase to exert anti-cancer effect
Potential Applications
- The development can help to reduce burden of CRC through clinical translation
- Proof-of-concept evidences on the therapeutic use of probiotics for preventing CRC development
Photos
Schematic diagram shows the experimental design, time line, and representative colonic morphologies of the Apcmin/+ mouse model
Streptococcus thermophilus and its Secreted Molecules for the Prevention of Colorectal Cancer
Inventors
Prof. WU Ka Kei
Department
Department of Anaesthesia and Intensive Care
Key Problem and Market Opportunity
- Colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of cancer death globally
- Recently, a healthy microbiota of the gut have been associated with the prevention of CRC development
- To develop a probiotic for preventing colorectal cancer
Key Advantages of the Technology
- S thermophilus was found to be depleted in patients with colorectal cancer
- Replenishing S thermophilus inhibited tumor formation in two mouse models of colorectal cancer
- S thermophilus was found to secrete beta-galactosidase to exert anti-cancer effect
Potential Applications
- The development can help to reduce burden of CRC through clinical translation
- Proof-of-concept evidences on the therapeutic use of probiotics for preventing CRC development
Photos
Schematic diagram shows the experimental design, time line, and representative colonic morphologies of the Apcmin/+ mouse model
Categories
Medical Therapeutics
CUHK Tech ID
P-2018-0857
Patents
US62/799,162
Reference
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